Evaluation of oxidized LDL using LOX-1 ligand activity
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چکیده
منابع مشابه
Oxidized LDL and LOX-1 in Experimental Sepsis
Oxidized low-density lipoproteins (oxLDL) and the lectin-like oxLDL receptor-1 (LOX-1) are upregulated in inflammation. Because of the importance of inflammation and capillary leakage in the impairment of the microcirculation, which in turn contributes to the development of sepsis and multiorgan failure, the role of oxidized LDL and LOX-1 as players of intestinal inflammation is of great intere...
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Endothelial dysfunction and oxLDL are believed to be early and critical events in atherogenesis. 6-Shogaol is the major bioactive compound present in Zingiber officinale and possesses the anti-atherosclerotic effect. However, the mechanisms remain poorly understood. The goal of this study was to investigate the effects of 6-shogaol on oxLDL-induced Human umbilical vein endothelial cells (HUVECs...
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Oxidized low-density lipoprotein (OxLDL) has been implicated as a proatherogenic factor with a pathological role in the induction of endothelial dysfunction. Endothelial cells bind and uptake OxLDL primarily through the scavenger receptor lectin-like oxidized-low-density lipoprotein receptor-1 (LOX-1), which is believed to mediate critical effects of OxLDL in endothelial cells. To examine the b...
متن کاملCrystal structure of mutant LOX-1, a receptor protein for oxidized LDL
Introduction LOX-1, the lectin-like oxidized low-density lipoprotein (LDL) receptor, is the major receptor for oxidized LDL (OxLDL). This enzyme plays a critical role in endothelial dysfunction and injury, leading to initiation and progression of atherosclerosis. LOX-1 belongs to the Ctype lectin family, and human LOX-1 constitutes of cytoplasmic domain, transmembrane domain (TM), NECK domain a...
متن کاملOxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects.
BACKGROUND C-reactive protein (CRP) exerts biological activity on vascular endothelial cells. This activity may promote atherothrombosis, but the effects of this activity are still controversial. Lectin-like oxidized LDL receptor-1 (LOX-1), the oxidized LDL receptor on endothelial cells, is involved in endothelial dysfunction induced by oxidized LDL. METHODS We used laser confocal microscopy ...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 2012
ISSN: 0915-7441,1880-8808
DOI: 10.2491/jjsth.23.306